Which vaccine is perfect – Risks and side effects

Which vaccine is perfect – Risks and side effects

Nowadays, we are all worry. We are not as worried about couvid-19, we are more worried about vaccination. Which vaccine is perfect or not for me or us. We are trying to know it. But we don’t know most of people that vaccine is not action on the person who has recovered. In addition, we need to know better about risks and side effects of vaccine.

Vaccination is safe and saves lives. The rapid development of COVID-19 vaccines has led people to ask questions. An overview of the responses is given here and it also affects the aspect you can expect.

Almost everyone around the world is hoping to get a vaccine against coronavirus in the near future. Some invented vaccines have been found to be safe and approved by health authorities in several countries.

At the same time, many people are hesitant. Because, when they want to protect themselves from infection, they also think about the possible side effects from the vaccine. They quickly developed doubts about whether the vaccines were actually safe and whether the possible side effects had been adequately studied.

Considering which vaccine reactions are normal, and which side effects are possible?

General response to vaccination

It is normal to have a specific reaction after vaccination: there may be redness and swelling or pain around the injection site. Fatigue, fever, headache and sore limbs are not uncommon in the first three days after vaccination.

Reactions to this common vaccine are usually mild and subside after a few days. They show that the vaccine is working. Because, it enhances immunity and the body forms antibodies against the infection which are only “marked” by the vaccine.

Accordingly, similar vaccine reactions have already been reported after receiving BioNtech-Pfizer, Moderna, AstraZeneca and Russian Sputnik V vaccines, which are already in use.

Rarely serious side effects

In addition to the general vaccination response, severe side effects such as allergic shock were sometimes seen in isolated cases after vaccination, which were reported in detail. However, these are isolated incidents.

By the approved vaccines are safe, according to the European Medicines Agency (EMA), the U.S. Food and Drug Administration (FDA) and the World Health Organization (WHO); Otherwise, they would not have approved the vaccines.

Some newer vaccines – so-called mRNA vaccines are different from established vaccines: they do not contain a weakened or killed virus. Instead, they contain only a blueprint for the components of the COVID-19 pathogen.

Other so-called vector vaccines, such as SARS-CoV-2, use harmful adenoviruses (such as cold viruses) as transporters to introduce superficial proteins to spike proteins, and the immune response.

Risks and side effects of the commonly mentioned bellow vaccines:

AstraZeneca vaccine

An incident occurred during a clinical trial in September in the British-Swedish organization AstraZeneca. Because one person developed spinal cord injury after being vaccinated. This brief test was stopped until a separate panel of experts determined that inflammation was probably not related to vaccination.

On the other hand, common vaccine reactions such as pain at the injection site, muscle aches, headaches, and fatigue occur only with the vaccine from AstraZeneca. However, vaccine responses were less frequent and milder in older individuals. This is a vector vaccine.

Biontech-Pfizer vaccine

At the approval stage, no serious side effects were reported with the German Bioentech and the American Pfizer company BNT 1622BB vaccine. Common vaccination responses, such as fatigue and headache, were less frequent and weaker in older patients.

Since, this mRNA vaccine is being used, some patients developed severe allergies as soon as the injection was given. In the United States, one patient and two Britons even suffered from anaphylactic shock associated with redness of the skin and shortness of breath.

Since these individuals were either not known to be allergic to certain vaccine components or had no previous illness. So, the British Medicines and Health Care Products Regulatory Authority (MHRA) has found that certain people are allergic to certain vaccine ingredients or have already had anaphylactic shock, against vaccination.

The manufacturers found no direct link to the vaccine in the case of any U.S. physician who died of brain hemorrhage due to immune thrombocytopenia 16 days after receiving the vaccine. It occurs when the immune system reduces the number of platelets.

A few days after the first vaccination, it was headlined that 33 people had died in Norway, all of whom were over 75 years of age and had a serious underlying disease. While manufacturers are still investigating the reasons, the Norwegian health authority has changed its guidelines for vaccinating elderly, vulnerable people against CVID-19. In the future, physicians will have to decide individually whether the benefits of treatment outweigh the risk of side effects.

Moderna vaccine

The US company Moderna mRNA-1273 vaccine is also a gene-based vaccine that is very similar in principle to the one from BioNTech/Pfizer.

According to the manufacturer and testing authorities, during the clinical trials, participants tolerated the vaccine well. The usual vaccination reactions were only mild or moderate and didn’t last long. However, , according to an interim report by an independent surveillance panel- almost 10% of those vaccinated with mRNA-1273 experienced fatigue.

The US Centers for Disease Control and Prevention’s (CDC) response to the modern vaccine is “rare.” The CDC based this assessment on the documentation of 4,041,396 doses of vaccine administered between December 21, 2020 and January 10, 2021. The CDC said none of the allergies were fatal.

Very few people receiving the Moderna vaccine have experienced facial nerve paralysis. However, it is not yet clear whether these reactions actually relate to the main components of the vaccine. It is possible that the side effects were not triggered by mRNA, but by lipid nanoparticles that act as carriers of mRNA and are later broken down by the body.

Isolated cases of facial paralysis are temporary in most cases. This happened during clinical trials of the Bioentech / Pfizer and Moderna vaccines, but also during ongoing vaccinations in Israel.

Russian Sputnik V vaccine

In early August 2020, the vector vaccine GAM-COVD-VAC (Sputnik V) was approved in Russia. But a few thousand subjects involved did not wait for the third stage examination. Sputnik V uses two individually modified adenoviruses (rAd26-S and rAd5-S).

The vaccine, developed by the Gamaleza Research Center in Moscow, is under considerable worldwide scrutiny because the Russian government has approved emergency use after a second round of trials. Nevertheless, the scientists who reviewed the study expressed concern about the possible manipulation of the data.

Therefore, Sputnik V is already being used not only in Russia, but also in many other countries, including Belarus, the United Arab Emirates (UAE), India, Brazil and Argentina.

January 2, Russian Health Minister Mikhail Murshko told reporters that more than 1.5 million doses had been delivered to Russian territory and that more than 600,000 people had been vaccinated.

According to the Russian Ministry of Health, so far only vaccine responses such as headaches or fever have been registered. In Argentina, 317 out of a total of 32,013 vaccinated people responded to the vaccination in general, according to the Argentine Ministry of Health.

No serious side effects were reported after the Sputnik V vaccine. Nevertheless, reservations seem to be higher in Russia, according to a Reuters report, in a survey conducted by the “Doctor’s Handbook” mobile application and cited by RBC. Said no.

Weighing the benefits and risks

Risks and side effects registered are just snapshots of the past months – it must be noted despite all the excitement about rapid vaccine development. Nothing is known yet about the long-term effects of individual vaccines. Only long-term studies that are available with vaccines worldwide and will be clear after approval will provide clarity.

In principle, the decision is always based on a risk-benefit assessment, said Christian Bogdan, director of the Institute of Clinical Microbiology, Immunology and Hygiene at Iranjen University Hospital, who is also a member of the Standing Committee on Vaccination (STICO). Robert Koch Institute (RKI).

The German Press Agency made the following calculation: “If an elderly person has a 20% chance of dying from a coronavirus infection and at the same time the risk of serious side effects of the tick is 1: 50,000 or less,” he said, “I would take that risk.”

There is still a lack of information about rare, possibly serious side effects, for example in rare pre-existing conditions or in specific risk groups such as those with specific allergies.

This type side effects become apparent only after vaccination of many people and after long observations. “So, there’s a residual risk,” Bogdan said. “How high it is will need to be tested in the coming months and years.”

In the case of children, Bogdan said they should not be vaccinated. He said their risk of dying from Kavid-19 is close to zero, and they still have a long life ahead of them.

According to Bogdan, pregnant or breastfeeding women should also not be vaccinated as a precaution, based on current data.

However, a recommendation from the US Centers for Disease Control (CDC) did not rule out vaccinating pregnant or breastfeeding mothers with the mRNA vaccine after medical examination and consultation.

Anyway, life is one. So be careful when vaccinating. In your case, you need to make sure that the vaccine is perfect and suitable for the body. Then take the vaccine. And yes, stay away from common vaccines.